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Cytokine release syndrome in a patient with colorectal cancer following vaccination with BNT162b2 (tozinameran) (preprint)
Samra Turajlic; Lewis Au; Annika Fendler; Scott Shepherd; Karolina Rzeniewicz; Maddalena Cerrone; Fiona Byrne; Eleanor Carlyle; Kim Edmonds; Lyra Del Rosario; John Shon; Winston Haynes; Barry Ward; Ben Shum; William Gordon; Camille Gerard; Wenyi Xie; Nalinie Joharatnam-Hogan; Kate Young; Andrew Furness; Lisa Pickering; James Larkin; Ruth Harvey; George Kassiotis; Sonia Gandhi; Charles Swanton; Charlotte Fribbens; Katalin Wilkinson; Robert Wilkinson; David Lau; Naureen Starling; Ian Chau.
researchsquare; 2021.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-355230.v1

ABSTRACT

We present a case of cytokine release syndrome (CRS) that occurred five days after vaccination with BTN162b2 (tozinameran), an mRNA COVID-19 vaccine, in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-y/IL-2R/IL-18/IL-16/IL-10), and steroid responsiveness.


Subject(s)
Thrombocytopenia , COVID-19 , Colorectal Neoplasms
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